The amantadine-sensitivity of recombinant and parental influenza virus strains
Identifieur interne : 002752 ( Main/Exploration ); précédent : 002751; suivant : 002753The amantadine-sensitivity of recombinant and parental influenza virus strains
Auteurs : M. Hamzawi ; R. Jennings ; C. W. PotterSource :
- Medical Microbiology and Immunology [ 0300-8584 ] ; 1981-07-01.
English descriptors
- Teeft :
- Amantadine, Amantadine hydrochloride, Amantadine sensitivity, Assay, Coding, Different series, Gene coding, Gene composition, Gene constellation, Gene derivation, Gene product, Genes coding, Growth inhibition, Influenza, Influenza virus, Influenza virus strains, Influenza viruses, Inhibitory effect, Mdck, Mdck cell monolayers, Mdck cells, Monolayers, Other workers, Parent virus, Parent viruses, Plaque, Plaque assay, Plaque reduction, Polypeptide analysis, Present study, Previous reports, Recombinant, Recombinant influenza, Recombinant influenza viruses, Recombinant strains, Recombinant viruses, Tpck trypsin, Virol, Virus, Virus replication, Virus strains.
Abstract
Abstract: Several wild-type influenza A strains together with recombinants derived from these strains, were tested for sensitivity to amantadine using the in vitro techniques of inhibition in egg-bit culture and plaque reduction in MDCK cells. The results obtained were analysed with reference to the derivation of the recombinants. Susceptibility to amantadine was related to the gene coding for matrix protein, and these data are in agreement with previous reports of studies using other series of influenza viruses.
Url:
DOI: 10.1007/BF02125525
Affiliations:
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Le document en format XML
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Hamzawi</name><affiliation><wicri:noCountry code="subField">Sheffield</wicri:noCountry></affiliation></author><author><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name><affiliation><wicri:noCountry code="subField">Sheffield</wicri:noCountry></affiliation></author><author><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name><affiliation><wicri:noCountry code="subField">Sheffield</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Medical Microbiology and Immunology</title><title level="j" type="abbrev">Med Microbiol Immunol</title><idno type="ISSN">0300-8584</idno><idno type="eISSN">1432-1831</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1981-07-01">1981-07-01</date><biblScope unit="volume">169</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="259">259</biblScope><biblScope unit="page" to="268">268</biblScope></imprint><idno type="ISSN">0300-8584</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-8584</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Amantadine</term><term>Amantadine hydrochloride</term><term>Amantadine sensitivity</term><term>Assay</term><term>Coding</term><term>Different series</term><term>Gene coding</term><term>Gene composition</term><term>Gene constellation</term><term>Gene derivation</term><term>Gene product</term><term>Genes coding</term><term>Growth inhibition</term><term>Influenza</term><term>Influenza virus</term><term>Influenza virus strains</term><term>Influenza viruses</term><term>Inhibitory effect</term><term>Mdck</term><term>Mdck cell monolayers</term><term>Mdck cells</term><term>Monolayers</term><term>Other workers</term><term>Parent virus</term><term>Parent viruses</term><term>Plaque</term><term>Plaque assay</term><term>Plaque reduction</term><term>Polypeptide analysis</term><term>Present study</term><term>Previous reports</term><term>Recombinant</term><term>Recombinant influenza</term><term>Recombinant influenza viruses</term><term>Recombinant strains</term><term>Recombinant viruses</term><term>Tpck trypsin</term><term>Virol</term><term>Virus</term><term>Virus replication</term><term>Virus strains</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Several wild-type influenza A strains together with recombinants derived from these strains, were tested for sensitivity to amantadine using the in vitro techniques of inhibition in egg-bit culture and plaque reduction in MDCK cells. The results obtained were analysed with reference to the derivation of the recombinants. Susceptibility to amantadine was related to the gene coding for matrix protein, and these data are in agreement with previous reports of studies using other series of influenza viruses.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Hamzawi, M" sort="Hamzawi, M" uniqKey="Hamzawi M" first="M." last="Hamzawi">M. Hamzawi</name><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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